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ARTWORK INFORMATION: PRODUCT: Periactin (Cyproheptadine HCl) 4 mg Tablets LICENCE: PL APPROVED FOR SUBMISSION: ITEM / SIZE: Generic package leaflet / 150 mm (w) x 520 mm (h) [flat] ID CODE: A1000338/2 VERSION: 1; INK: Black Note: this document will print at approx. 69% actual size when printed on A3 paper.

APPROVED BY HEALTH AUTHORITY: PACKAGE LEAFLET: INFORMATION FOR THE USER PERIACTIN® 4MG TABLETS (Cyproheptadine Hydrochloride) Read all of this leaflet carefully because it contains important information for you. This medicine is available without prescription. However, you still need to take Periactin carefully to get the best results from it. • Keep this leaflet. You may need to read it again. • Ask your pharmacist if you need more information or advice.

• You must contact a doctor if your symptoms worsen or do not improve. • If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. In this leaflet: 1. What Periactin is and what it is used for 2. Before you take Periactin 3. How to take Periactin 4.

Possible side effects 5. How to store Periactin 6. Further Information 1.

What Periactin is and what it is used for Periactin contains a medicine called cyproheptadine. This belongs to a group of medicines called ‘antihistamines’. In some illnesses too much ‘histamine’ and ‘serotonin’ are produced in the body. These occur naturally in your body. Periactin helps in these illnesses by stopping the unwanted effects of histamine and serotonin. Periactin is used for: • skin allergies with itchiness, swelling, or red skin, eczema or nettle rash • itchiness of chicken pox and reactions to insect bites and stings • sneezing, watery eyes and blocked or runny nose caused by an allergy (allergic rhinitis) • conjunctivis caused by an allergy- with red, watery, inflamed eyes • migraine and other similar headaches.

Before you take Periactin Do not take Periactin if: • you are allergic (hypersensitive) to cyproheptadine or any of the other ingredients of Periactin (listed in section 6 below) • you are taking a type of medicine called a monoamine oxidase inhibitor (MAOI) for depression, such as meclobemide, phenelzine, tranylcypramine, linezolid or pargyline. • you have a narrowing of the opening from the stomach (‘stricture’) • you have an eye problem called ‘glaucoma’ • you are being treated for an asthmatic attack • you are elderly and not very mobile • you have problems passing urine • you have a stomach ulcer. Do not take Periactin if any of the above apply to you.